We demonstrate several applications of differentiating optimal solutions of constraint-based metabolic models, and show how it connects to classic metabolic control analysis
PerMedCoE partners at Institut Curie and the University of Heidelberg developed a workflow that facilitates the prediction of personalised targeted drug combinations for cancer treatment, using CARNIVAL (Trairathphisan et al. 2021), PROFILE (Béal et al. 2019) and MaBoSS (Stoll et al. 2012, 2017) software. As a proof of concept, the workflow has successfully been run on the BSC MareNostrum 4 supercomputer.
Our Autumn agenda of courses cover topics such as data protection and security, cobrexa.ji and croupier.
Trainings, webinars & courses
Modelling biological systems can be very useful to identify which cellular mechanisms are deregulated in diseases and why, to anticipate the effect of drugs, and to optimise the efficacy of treatments, among other purposes. This section includes training materials and...
Webinar: Introducing PerMedCoE Building Blocks and Workflows to streamline biological analysis pipelines
👩🏾💻 15 December 2022 – Introducing PerMedCoE Building Blocks and Workflows to streamline biological analysis pipelines
👩🏾💻 25 January 2023 – Data-driven modelling of intercellular interactions in the tumour microenvironment
to run in pre-exascale
Use cases driving the
PerMed solutions in
the new European
professionals in the
use of HPC/Exascale
Building the basis
for the sustainability
of the PerMedCoE