The key core applications are currently licensed under different free software and/or open-source licenses that enable their adaptation and scale-up (PhysiCell: The 3-Clause BSD License, MaBoSS: GNU Lesser General Public License, some COBRA software: GNU General Public License 3, CellNOpt: GNU General Public License, version 2). The PerMedCoE will use the appropriate licenses to follow the CoE full commitment to open science and open software, based on a thorough licensing analysis, such as GPLv3/Apache/MIT. Furthermore, the PerMedCoE will consider that the commitment to code sharing extends to the use of collaborative platforms for code development and to the use of standard software development processes and practices, including formal code review and testing.